Antipsychotics

Explains what antipsychotics are used for, how the medication works, possible side effects and information about withdrawal.

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The different types of antipsychotics

This page contains comparison tables, presenting all antipsychotics by:

Why might I want to compare antipsychotics?

After considering how they can help and issues around taking them safely, you might want to know more about the different antipsychotics available to help you talk to your doctor about what's right for you. For example:

  • If you have problems with a particular type of drug, such as first generation (older) antipsychotics, and want to avoid them.
  • If you need your medication in a different form – for example, you may have problems with swallowing or find it hard to remember to take your medication correctly every day.
  • If you have any dietary restrictions, such as being vegetarian or intolerant to some ingredients.
  • If the drug's half-life is important to you – for example, if you are concerned about withdrawal effects and would prefer a drug with a longer half-life. For information about what the half-life means and why it matters, see our page about medication half-life.
  • If you are worried about the impact of particular side effects, such as weight gain. For information about the side effects of a particular antipsychotic, you can look the drug up in our antipsychotics A–Z.
Remember: drugs don't work the same way for everyone, and it's important to find a medication that works for you. See our page on receiving the right medication for more information.

Antipsychotics by generic name and key characteristics

Generic name Trade names (UK) Type of antipsychotic Forms available Half-life Dietary considerations
amisulpride Solian 2nd generation
  • tablets
  • liquid
about 12 hrs tablets contain lactose
aripiprazole Abilify 2nd generation
  • tablet
  • dissolving tablets
  • liquid
  • emergency injection
75–146 hrs tablets contain lactose (dissolving tablets do not)
aripiprazole Abilify Maintena 2nd generation depot 30–47 days none
asenapine Sycrest 2nd generation
  • dissolving tablet
about 24 hrs contains gelatine
benperidol Anquil 1st generation
  • tablets
6–10 hrs contains lactose
chlorpromazine Largactil 1st generation
  • tablets
  • liquid
  • emergency injection
  • suppositories
20–40 hrs tablets contain lactose
clozapine Clozaril Denzapine 2nd generation
  • tablets
6–26 hrs contains lactose
flupentixol Depixol, Fluanxol, Flupenthixol 1st generation
  • tablets
about 35 hrs contains lactose
flupentixol decanoate Depixol 1st generation depot about 21 days contains coconut oil
fluphenazine decanoate Modecate 1st generation depot 6–9 days contains sesame oil
haloperidol Dozic, Haldol, Serenace 1st generation about 20 hrs tablets contain lactose
haloperidol decanoate Haldol decanoate 1st generation depot about 21 days contains sesame oil
levomepromazine Nozinan 1st generation
  • tablets
about 30 hrs none
lurasidone Latuda 2nd generation
  • tablets
20–40 hrs none
olanzapine Zyprexa 2nd generation
  • tablets
  • dissolving tablets (Velotab)
  • emergency injection
32–52 hrs tablets contain lactose
(dissolving tablets do not)
olanzapine pamoate monohydrate ZypAdhera 2nd generation depot about 30 days none
paliperidone Invega 2nd generation
  • slow release tablets
about 23 hrs 3mg tablets contain lactose
paliperidone palmitate Xeplion 2nd generation
depot
25–49 days none
pericyazine Neulactil 1st generation
  • tablets
  • liquid
about 12 hrs tablets contain lactose
perphenazine Fentazin 1st generation
  • tablets
8–20 hrs contains lactose
pimozide Orap 1st generation
  • tablets
about 55 hrs none
pipotiazine palmitate
(discontinued in 2015)
Piportil depot 1st generation depot not available contains sesame oil
prochlorperazine Stemetil 1st generation 4–8 hrs tablets contain lactose
promazine none 1st generation
  • tablets
  • liquid
not available tablets contain lactose
quetiapine Atrolak
Biquelle
Ebesque
Seroquel
Tenprolide
Zaluron
2nd generation
  • tablets
7–12 hrs contains lactose
risperidone Risperdal 2nd generation
  • tablets
  • dissolving tablets (Quicklet)
about 24 hrs contains lactose
some tablets contain gelatin
risperidone Risperdal Consta 2nd generation depot
  • injection
4–6 days none
sulpiride Dolmatil
Sulpor
1st generation
  • tablets
  • liquid
about 8 hrs tablets contain lactose
trifluoperazine Stelazine 1st generation
  • tablets
  • liquid
about 22 hrs tablets contain gelatin
zuclopenthixol Clopixol Acuphase 1st generation
  • emergency injection
about 19 days contains thin coconut oil
zuclopentixol decanoate Clopixol 1st generation depot about 19 days contains thin vegetable oil
zuclopenthixol dihydrochloride Clopixol 1st generation
  • tablets
about 24 hrs contains lactose

*dispersible tablets will disintegrate quickly in the mouth or can be mixed with water, orange juice or apple juice

Comparing antipsychotics by type

Type of antipsychotic

Drug names

1st generation

  • benperidol
  • flupentixol
  • haloperidol
  • levomepromazine
  • pericyazine
  • perphenazine
  • pimozide
  • prochlorperazine
  • promazine
  • sulpiride
  • trifluoperazine
  • zuclopenthixol
  • zuclopenthixol dihydrochloride

1st generation depot

  • flupentixol decanoate
  • fluphenazine decanoate
  • haloperidol decanoate
  • pipotiazine palmitate
  • zuclopentixol decanoate

2nd generation

  • amisulpride
  • aripiprazole
  • asenapine
  • clozapine
  • lurasidone
  • olanzapine
  • paliperidone
  • quetiapine
  • risperidone

2nd generation depot

 

  • aripiprazole
  • olanzapine pamoate monohydrate
  • paliperidone palmitate
  • risperidone

Comparing antipsychotics by half-life

(For information about what the half-life means and why it matters, see our page on medication half-life).

Half-life

Drug name

4–8 hours

prochlorperazine

6–10 hours benperidol
6–26 hours clozapine
7–12 hours quetiapine
about 8 hours sulpiride
8–20 hours perphenazine
about 12 hours amisulpride
about 12 hours pericyazine
about 20 hours haloperidol
20–40 hours chlorpromazine
20–40 hours lurasidone
about 22 hours trifluoperazine
about 23 hours paliperidone
about 24 hours asenapine
about 24 hours risperidone
about 24 hours zuclopenthixol dihydrochloride
about 30 hours levomepromazine
32–52 hours olanzapine
about 35 hours  flupentixol
about 55 hours pimozide
75–146 hours aripiprazole
4–6 days risperidone (depot)
6–9 days fluphenazine decanoate
about 19 days zuclopenthixol
about 19 days zuclopentixol decanoate
about 21 days flupentixol decanoate
about 21 days haloperidol decanoate
25–49 days paliperidone palmitate
about 30 days olanzapine pamoate monohydrate
30–47 days aripiprazole (depot)
n/a pipotiazine palmitate
n/a promazine

Comparing antipsychotics by form available

Form

Antipsychotics available in this form

tablets

  • amisulpride
  • aripiprazole
  • benperidol
  • chlorpromazine
  • clozapine
  • flupentixol
  • haloperidol
  • levomepromazine
  • lurasidone
  • olanzapine
  • paliperidone
  • pericyazine
  • perphenazine
  • pimozide
  • prochlorperazine
  • promazine
  • quetiapine
  • risperidone
  • sulpiride
  • trifluoperazine
  • zuclopenthixol dihydrochloride

dissolving tablets

  • aripiprazole
  • asenapine
  • olanzapine
  • risperidone

liquid

  • amisulpride
  • aripiprazole
  • chlorpromazine
  • haloperidol
  • pericyazine
  • prochlorperazine
  • promazine
  • sulpiride
  • trifluoperazine

injection

  • aripiprazole
  • chlorpromazine
  • flupentixol decanoate
  • fluphenazine decanoate
  • haloperidol
  • haloperidol decanoate
  • olanzapine
  • olanzapine pamoate monohydrate
  • paliperidone palmitate
  • pipotiazine palmitate
  • prochlorperazine
  • risperidone
  • zuclopenthixol
  • zuclopentixol decanoate

suppositories

  • chlorpromazine
   

Comparing antipsychotics by dietary considerations

Dietary consideration Drugs this applies to

Contains lactose

  • amisulpride
  • aripiprazole
  • benperidol
  • chlorpromazine
  • clozapine
  • flupentixol
  • haloperidol
  • olanzapine
  • paliperidone
  • pericyazine
  • perphenazine
  • prochlorperazine
  • promazine
  • quetiapine
  • risperidone
  • sulpiride
  • zuclopenthixol dihydrochloride

Contains gelatine

  • asenapine
  • risperidone (some tablets)
  • trifluoperazine

Contains coconut oil

  • flupentixol decanoate
  • zuclopenthixol

Contains sesame oil

  • fluphenazine decanoate
  • haloperidol decanoate
  • pipotiazine palmitate

 This information was published in 2016. We will revise it in 2018.


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