for better mental health

Antipsychotics

Explains what antipsychotics are used for, how the medication works, possible side effects and information about withdrawal.

Why might I want to compare antipsychotics?

Understanding more about the different antipsychotics available may help you talk to your doctor or psychiatrist about what's right for you, including:

  • If you’ve experienced problems with a particular type of antipsychotic and want to avoid them. For example, if you’ve experienced problems with a first generation (older) antipsychotic and want to change to a newer drug.
  • If you need your medication in a different form. For example, you may have problems with swallowing or find it hard to remember to take your medication correctly every day.
  • If you have any dietary restrictions, such as being vegetarian or intolerant of some ingredients.
  • If the drug's half-life is important to you. For example, if you are concerned about withdrawal effects and would prefer a drug with a longer half-life. For information about what the half-life means and why it matters, see our page about medication half-life.
  • If you are worried about certain side effects of your medication.

Remember: drugs don't work the same way for everyone, and it's important to find a medication that works for you. See our page on receiving the right medication for more information.

Antipsychotics by generic name and key characteristics

Each of these drugs may be known by several different names, which we have listed below under the Generic name and Trade names columns. See our page on drug names for more information.

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Generic name Trade names (UK) Type of antipsychotic Forms available Half-life Dietary considerations
amisulpride Solian 2nd generation
  • tablets
  • liquid
about 12 hours tablets contain lactose
aripiprazole Abilify, Arpoya 2nd generation
  • tablets
  • dissolving tablets
  • liquid
  • emergency injection
75–146 hours tablets contain lactose
aripiprazole (depot) Abilify Maintena 2nd generation depot 29–46 days none
asenapine Sycrest 2nd generation
  • dissolving tablets
about 24 hours contains gelatine
benperidol Anquil 1st generation
  • tablets
6–10 hours contains lactose
cariprazine Reagila 2nd generation
  • capsules
2–8 days contains gelatine
chlorpromazine Chloractil, Largactil 1st generation
  • tablets
  • liquid
  • emergency injection
  • suppositories
about 30 hours tablets contain lactose and gelatine
clozapine Clozaril, Denzapine, Zaponex 2nd generation
  • tablets
  • dissolving tablets
  • liquid suspension
6–26 hours tablets contain lactose
flupentixol Depixol, Fluanxol 1st generation
  • tablets
about 35 hours contains lactose
flupentixol decanoate Depixol, Psytixol 1st generation depot 17–21 days contains coconut oil
fluphenazine decanoate Modecate 1st generation depot 2.5–16 weeks contains sesame oil
haloperidol Haldol, Halkid 1st generation
  • tablets
  • liquid
  • emergency injection
21–24 hours some tablets contain lactose
haloperidol decanoate Haldol decanoate 1st generation depot about 21 days contains sesame oil
levomepromazine Nozinan 1st generation
  • tablets
about 30 hours none
lurasidone Latuda 2nd generation
  • tablets
20–40 hours none
olanzapine Zalasta, Zyprexa 2nd generation
  • tablets
  • dissolving tablets (Velotab)
  • emergency injection
31–52 hours tablets contain lactose
(dissolving tablets do not)
olanzapine pamoate monohydrate Zypadhera 2nd generation depot about 30 days none
paliperidone Invega 2nd generation
  • slow-release tablets
about 23 hours 3mg tablets contain lactose
paliperidone palmitate Trevicta, Xeplion 2nd generation
depot

Trevicta: 84–139

Xeplion: 25–49 days

none
pericyazine Neulactil 1st generation
  • tablets
  • liquid
about 12 hours tablets contain lactose
pimozide Orap 1st generation
  • tablets
55–150 hours none
prochlorperazine Stemetil 1st generation
  • tablets
  • liquid
  • emergency injection
4–9 hours tablets contain lactose
promazine none 1st generation
  • tablets
  • liquid
20–40 hours tablets contain lactose
quetiapine

Alaquet, Atrolak, Biquelle, Branco, Mintreleg, Seroquel, Tenprolide, 
Zaluron

2nd generation
  • tablets
  • slow-release tablets
7–12 hours some tablets contain lactose
risperidone Risperdal 2nd generation
  • tablets
  • dissolving tablets (Quicklet)
  • liquid
3–20 hours tablets contain lactose
some tablets contain gelatine
risperidone (depot) Risperdal Consta 2nd generation depot 3–6 days none
sulpiride Dolmatil, Sulpor 1st generation
  • tablets
  • liquid
about 8 hours tablets contain lactose
trifluoperazine Stelazine 1st generation
  • tablets
  • liquid
about 22 hours tablets contain gelatine
zuclopenthixol Clopixol Acuphase 1st generation
  • emergency injection
about 19 days contains thin coconut oil
zuclopenthixol decanoate Clopixol 1st generation depot about 19 days contains thin vegetable oil
zuclopenthixol dihydrochloride Clopixol 1st generation
  • tablets
about 24 hours contains lactose

Antipsychotics by type

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Type of antipsychotic

Antipsychotics in this type

1st generation

  • benperidol
  • flupentixol
  • haloperidol
  • levomepromazine
  • pericyazine
  • pimozide
  • prochlorperazine
  • promazine
  • sulpiride
  • trifluoperazine
  • zuclopenthixol
  • zuclopenthixol dihydrochloride

1st generation depot

  • flupentixol decanoate
  • fluphenazine decanoate
  • haloperidol decanoate
  • zuclopentixol decanoate

2nd generation

  • amisulpride
  • aripiprazole
  • asenapine
  • cariprazine
  • clozapine
  • lurasidone
  • olanzapine
  • paliperidone
  • quetiapine
  • risperidone

2nd generation depot

 

  • aripiprazole
  • olanzapine pamoate monohydrate
  • paliperidone palmitate
  • risperidone

Antipsychotics by half-life

For information about what the half-life means and why it matters, see our page on medication half-life.

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Half-life

Antipsychotic

3–20 hours

risperidone

4–9 hours

prochlorperazine

6–10 hours benperidol
6–26 hours clozapine
7–12 hours quetiapine
about 8 hours sulpiride
about 12 hours amisulpride
about 12 hours pericyazine
20–40 hours lurasidone
20–40 hours promazine
21–24 hours haloperidol
about 22 hours trifluoperazine
about 23 hours paliperidone
about 24 hours asenapine
about 24 hours zuclopenthixol dihydrochloride
about 30 hours chlorpromazine
about 30 hours levomepromazine
31–52 hours olanzapine
about 35 hours  flupentixol
55–150 hours pimozide
75–146 hours aripiprazole
2–8 days cariprazine
3–6 days risperidone (depot)
17–112 days fluphenazine decanoate
17–21 days flupentixol decanoate
about 19 days zuclopenthixol
about 19 days zuclopentixol decanoate
about 21 days haloperidol decanoate
25–139 days paliperidone palmitate
29–46 days aripiprazole (depot)
about 30 days olanzapine pamoate monohydrate

Antipsychotics by form available

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Form

Antipsychotics available in this form

tablets

  • amisulpride
  • aripiprazole
  • benperidol
  • chlorpromazine
  • clozapine
  • flupentixol
  • haloperidol
  • levomepromazine
  • lurasidone
  • olanzapine
  • paliperidone
  • pericyazine
  • pimozide
  • prochlorperazine
  • promazine
  • quetiapine
  • risperidone
  • sulpiride
  • trifluoperazine
  • zuclopenthixol dihydrochloride

dissolving tablets

  • aripiprazole
  • asenapine
  • clozapine
  • olanzapine
  • risperidone

capsules

  • cariprazine

liquid

  • amisulpride
  • aripiprazole
  • chlorpromazine
  • haloperidol
  • pericyazine
  • prochlorperazine
  • promazine
  • sulpiride
  • trifluoperazine

injection

  • aripiprazole
  • chlorpromazine
  • flupentixol decanoate
  • fluphenazine decanoate
  • haloperidol
  • haloperidol decanoate
  • olanzapine
  • olanzapine pamoate monohydrate
  • paliperidone palmitate
  • prochlorperazine
  • risperidone
  • zuclopenthixol
  • zuclopentixol decanoate

suppositories

  • chlorpromazine

Antipsychotics by dietary considerations

Certain brands of individual drugs may have other dietary restrictions that aren’t listed in the tables below. If you are concerned about this, you can check the Patient Information Leaflet (PIL) included in the box with your medication. This will include a full list of your medication's ingredients. 

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Dietary consideration Antipsychotics with these considerations

Contains lactose

(only applies to the tablet form of the drug, unless specified)

  • amisulpride
  • aripiprazole
  • benperidol
  • chlorpromazine
  • clozapine
  • flupentixol
  • haloperidol
  • olanzapine (non-dissolving tablets only)
  • paliperidone (3mg tablets only)
  • pericyazine
  • prochlorperazine
  • promazine
  • quetiapine (some tablets)
  • risperidone
  • sulpiride
  • zuclopenthixol dihydrochloride

Contains gelatine

  • asenapine
  • cariprazine
  • chlorpromazine (tablets only)
  • risperidone (some tablets)
  • trifluoperazine

Contains coconut oil

  • flupentixol decanoate
  • zuclopenthixol

Contains sesame oil

  • fluphenazine decanoate
  • haloperidol decanoate
  • pipotiazine palmitate

Contains vegetable oil

  • zuclopenthixol decanoate

 

This information was published in September 2020. We will revise it in 2023.

References are available on request. If you would like to reproduce any of this information, see our page on permissions and licensing.

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