Explains what antipsychotics are used for, how the medication works, possible side effects and information about withdrawal.
Why might I want to compare antipsychotics?
Understanding more about the different antipsychotics available may help you talk to your doctor or psychiatrist about what's right for you, including:
- If you’ve experienced problems with a particular type of antipsychotic and want to avoid them. For example, if you’ve experienced problems with a first generation (older) antipsychotic and want to change to a newer drug.
- If you need your medication in a different form. For example, you may have problems with swallowing or find it hard to remember to take your medication correctly every day.
- If you have any dietary restrictions, such as being vegetarian or intolerant of some ingredients.
- If the drug's half-life is important to you. For example, if you are concerned about withdrawal effects and would prefer a drug with a longer half-life. For information about what the half-life means and why it matters, see our page about medication half-life.
- If you are worried about certain side effects of your medication.
Each of these drugs may be known by several different names, which we have listed below under the Generic name and Trade names columns. See our page on drug names for more information.
|Generic name||Trade names (UK)||Type of antipsychotic||Forms available||Half-life||Dietary considerations|
||around 12 hours||tablets contain lactose|
|aripiprazole||Abilify, Arpoya||2nd generation||
||75 to 146 hours||tablets contain lactose|
|aripiprazole (depot)||Abilify Maintena||2nd generation depot||29 to 46 days||none|
||around 24 hours||contains gelatine|
||6 to 10 hours||contains lactose|
||2 to 8 days||contains gelatine|
|chlorpromazine||Chloractil, Largactil||1st generation||
||around 30 hours||tablets contain lactose and gelatine|
|clozapine||Clozaril, Denzapine, Zaponex||2nd generation||
||6 to 26 hours||tablets contain lactose|
|flupentixol||Depixol, Fluanxol||1st generation||
||around 35 hours||contains lactose|
|flupentixol decanoate||Depixol, Psytixol||1st generation depot||17 to 21 days||contains coconut oil|
|fluphenazine decanoate||Modecate||1st generation depot||2.5 to 16 weeks||contains sesame oil|
|haloperidol||Haldol, Halkid||1st generation||
||21 to 24 hours||some tablets contain lactose|
|haloperidol decanoate||Haldol decanoate||1st generation depot||around 21 days||contains sesame oil|
||around 30 hours||none|
||20 to 40 hours||none|
|olanzapine||Zalasta, Zyprexa||2nd generation||
||31 to 52 hours||tablets contain lactose
(dissolving tablets do not)
|olanzapine pamoate monohydrate||Zypadhera||2nd generation depot||around 30 days||none|
||around 23 hours||3mg tablets contain lactose|
|paliperidone palmitate||Trevicta, Xeplion||2nd generation
Trevicta: 84 to 139 days
Xeplion: 25 to 49 days
||around 12 hours||tablets contain lactose|
||55 to 150 hours||none|
||4 to 9 hours||tablets contain lactose|
||20 to 40 hours||tablets contain lactose|
Alaquet, Atrolak, Biquelle, Branco, Mintreleg, Seroquel, Tenprolide,
||7 to 12 hours||some tablets contain lactose|
||3 to 20 hours||tablets contain lactose
some tablets contain gelatine
|risperidone (depot)||Risperdal Consta||2nd generation depot||3 to 6 days||none|
|sulpiride||Dolmatil, Sulpor||1st generation||
||around 8 hours||tablets contain lactose|
||around 22 hours||tablets contain gelatine|
|zuclopenthixol||Clopixol Acuphase||1st generation||
||around 19 days||contains thin coconut oil|
|zuclopenthixol decanoate||Clopixol||1st generation depot||around 19 days||contains thin vegetable oil|
|zuclopenthixol dihydrochloride||Clopixol||1st generation||
||around 24 hours||contains lactose|
Type of antipsychotic
Antipsychotics in this type
1st generation depot
2nd generation depot
For information about what the half-life means and why it matters, see our page on medication half-life.
|3 to 20 hours|
|4 to 9 hours|
|6 to 10 hours||benperidol|
|6 to 26 hours||clozapine|
|7 to 12 hours||quetiapine|
|around 8 hours||sulpiride|
|around 12 hours||amisulpride|
|around 12 hours||pericyazine|
|20 to 40 hours||lurasidone|
|20 to 40 hours||promazine|
|21 to 24 hours||haloperidol|
|around 22 hours||trifluoperazine|
|around 23 hours||paliperidone|
|around 24 hours||asenapine|
|around 24 hours||zuclopenthixol dihydrochloride|
|around 30 hours||chlorpromazine|
|around 30 hours||levomepromazine|
|31 to 52 hours||olanzapine|
|around 35 hours||flupentixol|
|55 to 150 hours||pimozide|
|75 to 146 hours||aripiprazole|
|2 to 8 days||cariprazine|
|3 to 6 days||risperidone (depot)|
|17 to 112 days||fluphenazine decanoate|
|17 to 21 days||flupentixol decanoate|
|around 19 days||zuclopenthixol|
|around 19 days||zuclopenthixol decanoate|
|around 21 days||haloperidol decanoate|
|25 to 139 days||paliperidone palmitate|
|29 to 46 days||aripiprazole (depot)|
|around 30 days||olanzapine pamoate monohydrate|
Antipsychotics available in this form
dispersible (dissolving) tablets
Certain brands of individual drugs may have other dietary restrictions that aren’t listed in the tables below. If you are concerned about this, you can check the Patient Information Leaflet (PIL) included in the box with your medication. This will include a full list of your medication's ingredients.
|Dietary consideration||Antipsychotics with these considerations|
(only applies to the tablet form of the drug, unless specified)
Contains coconut oil
Contains sesame oil
Contains vegetable oil
This information was published in September 2020. We will revise it in 2023.
References and bibliography available on request.
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