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Seroxat
March 2008
Legislation proposed to require drug companies to make all results of drug trials available to the MHRA.
'Drugs firms face new laws on test results' The Guardian, Thursday March 6 2008.
This arises from Glaxo Smith Kline's failure to disclose the negative effects of Seroxat in children.
MHRA press release.
Information on Seroxat to accompany the broadcast of Panorama: Secrets of the drugs trials, Monday 29 January, 2007.
Press enquiries
What the textbooks and datasheet say - includes official guidance on prescribing for children.
NICE guideline on depression in children and young people
Paper by David Healy, Andrew Herxheimer and David B Menkes, Antidepressants and violence: problems at the interface of medicine and law, published September, 2006, Public Library of Science, Medicine.
Reporting adverse effects (including withdrawal effects) of medicines
Adverse effects of medicines can be reported to the Medicines and Healthcare products Regulatory Agency (MHRA) by members of the public, as well as by health professionals. There are three ways to do this: on the MHRA website, by telephone, and on Yellow Card forms available from pharmacies. Adverse effects of all medicines can be reported, included over-the-counter medicines and herbal remedies. You can also see a summary of adverse effects reported for each drug on the website.
Note:
Mind has drawn attention to the problems associated with Seroxat (paroxetine) but it is important to remember that many people find it beneficial and do not have bad reactions.
Mind outlines MHRA reminder on maximum dosage of Seroxat, issued 11 March 2004.
Information about withdrawal - including possible symptoms and a withdrawal plan written by Dr David Healy.
Panorama: 'Taken on trust', broadcast October, 2004.
Panorama: 'Seroxat: emails from the edge', broadcast May 2003.
Panorama: 'The secrets of Seroxat', broadcast October 2002.
Personal experiences and resources - including personal stories, a Mind briefing and links to online booklets.
Read Dr David Healy's submission to the FDA on the Alliance for Human Research Protection (AHRP) website.
Mind policy paper on Medicine regulation in the UK (pdf format).
Mind's booklets
If you are stopping taking medication it is advisable to reduce the dose gradually, as it is difficult to predict who will have problems withdrawing. It is worth getting as much information and support as you can, and involving your doctor wherever possible.
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